Introduction: Seed-based analysis has shown that transcutaneous auricular vagus nerve stimulation (taVNS) can modulate the dysfunctional brain network in patients with major depressive disorder (MDD). However, the voxel-based neuropsychological mechanism of taVNS on patients with first-episode MDD is poorly understood. The objective of this study was to assess the effects of an 8-week course of taVNS on patients with first-episode MDD. Methods: Twenty-two patients with first-episode MDD accepted an 8-week course of taVNS treatment. Resting-state functional magnetic resonance imaging (rs-fMRI) scans were performed before and after treatment. Voxel-based analyses were performed to characterize spontaneous brain activity. Healthy controls (n=23) were recruited to minimize test-retest effects. Analysis of covariance (ANCOVA) was performed to ascertain treatment-related changes. Then, correlations between changes in brain activity and the Hamilton Depression Rating Scale (HAM-D)/Hamilton Anxiety Scale (HAM-A) remission rate were estimated. Results: Significant group-by-time interactions on voxel-based analyses were observed in the inferior ventral striatum (VSi) and precuneus. Post-hoc analyses showed that taVNS inhibited higher brain activity in the VSi, while upregulating it in the precuneus. Functional connectivity (FC) between the VSi and precuneus decreased. Positive correlations were found between the HAM-D remission rate and changes in brain activity in the VSi. Conclusion: taVNS reduced the FC between VSi and precuneus by normalizing the abnormal spontaneous brain activity of VSi in first-episode MDD patients.

Abstract The study investigated that clinic significance and molecular mechanism of Plin5 in spinal cord injury (SCI). Serum levels of Plin5 was down-regulated and there is a negative correlation between Plin5 and IL-1β levels in patients with SCI,. Human Plin5 protein could reduce inflammation, and prevented spinal cord injury in rat model of SCI. Over-expression of Plin5 reduced inflammation divisors via activation of SIRT1 and suppression of NLRP3 in vitro model of SCI; down-regulation of Plin5 promoted inflammation divisors via inactivation of SIRT1 and induction of NLRP3 in vitro model of SCI. SIRT1 is important targets of Plin5 in inflammation divisors of SCI. The inhibition of SIRT1 reduced the effects of Plin5 on inflammation divisors of SCI. The activation of NLRP3 also reduced the effects of Plin5 on inflammation divisors of SCI. We concluded that clinic Serum levels of Plin5 is therapeutic target of SCI and Plin5 reduced inflammation in SCI via SIRT1 dependent suppression of NLRP3 Inflammasome.

Abstract On the increasing prevalence of using mAbs (monoclonal antibodies) in cancer therapy and the severe risk of hyperglycemia, we aimed to analyze the main clinical ADRs of mAbs, with a focus on adverse hyperglycemic events associated with currently clinically used mAbs. mAbs as well as target information were selected from Martinadale book and published articles. Drug approving information was collected from each government website, and ADR statistic data were collected from VigibaseR, comparing with Adverse Event Reporting System of US FDA. Top 10 mAbs were classified within listing in total ADR records, ADRs per year, hyperglycemic ADR records. Vigibase data were updated onto 15 Feb 2019. 20 mAbs were analyzed with 263217 ADR reports, wherein 16751 records on Metabolism and nutrition disorders and 1444 records on Glucose metabolism disorders. The geographic, age, gender distributions and annual ADR report numbers were listed respectively. Of the top 10, Rituximab, Bevacizumab and Nivolumab were on the top 3 in total ADR record and hyperglycemic record. Top 3 record results were similar in Vigibase and FDA database. It is of increasing importance for clinicians to be aware of early detection, patient management, or drug selection strategies when using mAbs, particularly within the high glycemic risk-reported mAbs, to improve the efficacy and tolerability of mAbs regiment and optimize patient outcomes.

RESUMO Introdução Nos últimos anos, a aptidão física das pessoas continua apresentando um lento declínio, por isso a manutenção da saúde humana é muito importante. Objetivo a tese pesquisa o efeito dos esportes coletivos de alunos e analisa os fatores que os influenciam. Método a tese usa estatística matemática para estudar as atividades esportivas e os fatores de influência dos grupos de alunos. Resultados O grupo de alunos não está satisfeito com as atividades esportivas extracurriculares realizadas pela escola. A comunidade tem pouca influência no comportamento esportivo do grupo de alunos. Conclusão Este estudo fornece uma base teórica e realista para o grupo de alunos implementar os documentos, regras e regulamentos do esporte escolar, e opiniões e promover a saúde física e mental do grupo de alunos. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

ABSTRACT Introduction In recent years, people’s physical fitness continues to show a slow decline, so the maintenance of human health is very important. Object The thesis researches the effect of student group sports and analyzes the influencing factors of student group sports. Method The thesis uses mathematical statistics to study student groups’ sports activities and influencing factors. Results The student group is not satisfied with the extracurricular sports activities carried out by the school. The community has little influence on the sports behavior of the student group. Conclusion This study provides a realistic and theoretical basis for the student group to implement the school sports documents, rules and regulations, and opinions and promote the student group’s physical and mental health. Level of evidence II; Therapeutic studies - investigation of treatment results.

RESUMEN Introducción En los últimos años, la condición física de las personas continúa mostrando un lento declive, por lo que el mantenimiento de la salud humana es muy importante. Objeto La tesis investiga el efecto de los deportes de grupo de estudiantes y analiza los factores que influyen en los deportes de grupo de estudiantes. Método La tesis utiliza estadística matemática para estudiar las actividades deportivas de los grupos de estudiantes y los factores de influencia. Resultados El grupo de estudiantes no está satisfecho con las actividades deportivas extraescolares que realiza la escuela. La comunidad tiene poca influencia en el comportamiento deportivo del grupo de estudiantes. Conclusión Este estudio proporciona una base realista y teórica para que el grupo de estudiantes implemente los documentos, reglas y regulaciones y opiniones de deportes escolares y promueva la salud física y mental del grupo de estudiantes. Nivel de evidencia II; Estudios terapéuticos: investigación de los resultados del tratamiento.